There's always a local amatuer musician playing here, the beer is the right price and on Sunday nights they are the host to one of Prague's best open mic scenes (I often play there, so I should know). There's always a welcoming and friendly crowd here along with a house guitar, so don't be shy! Every other night, it's an easy place to meet expats.
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If you want to do an open mic here in Prague, this is the place to do it - they host every week on Sunday night, starting at around 9. They also have free live music Wednesday through Saturday, so it's also a great place to get acquainted with the music scene.
Sunday nights for open mics!
Su: 17:00-02:00
Mon-Th: 17:00-03:00
Fr-Sa: 17:00-05:00